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From Gut to Brain and Back Again: How They Impact Each Other

Dr Stephen Wangen
|
October 7, 2025

You’ve probably felt it before: your stomach in knots during a stressful day, or a “gut feeling” that shaped an important decision. That’s no coincidence—it’s the gut-brain connection at work. But here’s what most people don’t realize: this isn’t a one-way street. The brain and gut are in constant two-way communication, each profoundly influencing the other. And when things go wrong, stress doesn’t usually create digestive problems on its own—it makes existing gut issues worse.

The Two-Way Street Between Gut and Brain

The gut and brain communicate through a network called the gut-brain axis, with the vagus nerve acting like a high-speed highway. Signals travel in both directions: from the gut to the brain, and from the brain back to the gut.

Your gut microbiome—trillions of bacteria and other microorganisms living in your digestive tract—plays a starring role in this conversation. These microbes help regulate digestion, immune function, and even produce neurotransmitters like serotonin and dopamine. In fact, about 90% of serotonin is made in the gut, not the brain.

This means your gut health can directly influence how you feel, think, and respond to stress. But equally important, your brain can alter how your gut functions. The two systems are partners, not rivals.

Why Stress Doesn’t Tell the Whole Story

It’s true that stress can trigger digestive symptoms—but it’s rarely the root cause. Stress alone usually doesn’t create chronic digestive problems. Instead, it tends to exacerbate an underlying weakness or imbalance in the gut.

For example:

• Someone with IBS might notice flare-ups during stressful times.

• A person with bacterial overgrowth or food intolerances may feel worse when under pressure.

But in both cases, stress is pouring gasoline on a fire that already exists. The real issue is the underlying gut problem that needs to be addressed. Until that root cause is dealt with, stress management can only do so much.

When the Brain Impacts the Gut

When you’re under stress, your brain can change how your gut moves, processes food, and even how sensitive it feels. This might mean bloating, urgency, or constipation.

But remember—these changes usually highlight what’s already fragile in your digestive system. If your gut were completely healthy, stress would have a much smaller impact.

When the Gut Impacts the Brain

On the other side of the street, gut health strongly influences mental well-being. An imbalanced microbiome, sometimes called dysbiosis, can interfere with neurotransmitter production, promote inflammation, and contribute to issues like anxiety, depression, and brain fog. I see this in patients almost every day.

This explains why so many people with digestive issues also experience mood swings, low energy, or trouble concentrating. When the gut is unhealthy, the brain feels it. And when the gut improves, mental clarity and resilience often improve too.

Supporting Both Ends of the Street

The key is to support both gut and brain health, while recognizing that the gut often needs to be addressed first. Here are some practical ways to strengthen this two-way relationship:

1. Identify and fix underlying gut problems – Don’t just mask symptoms; get to the root cause of issues like food intolerances, microbiome imbalances, or chronic inflammation. Most doctors don’t do that.

2. Nourish your microbiome – Eat really healthy, such as fiber-rich plant foods, prebiotics, and fermented foods that encourage healthy bacteria.

3. Use stress management as a supportive tool – Practices like meditation, breathwork, yoga, and sound therapy calm the nervous system, reducing the intensity of gut reactions.

4. Prioritize restorative sleep – A strong circadian rhythm supports both gut repair and mental health.

5. Consider probiotics and targeted therapies – High-quality probiotics and professional care can help restore balance.

Closing

The gut-brain connection is a dynamic two-way street. Stress doesn’t create chronic digestive problems from thin air—it usually magnifies what’s already there. That’s why lasting relief often begins with healing the gut itself. When you restore digestive health, you don’t just calm the stomach—you also calm the mind.

I’ve seen this happen hundreds of times in my patients. Maybe thousands.

So if you’ve been told your gut issues are “just stress,” don’t settle for that answer. Look deeper, address the underlying gut imbalance, and watch as both your digestion and your mental well-being transform.

If you need help with this, give us a call at the IBS Treatment Center. Distance is not an issue. We work with people around the world via telemedicine, and we’d be happy to work with you too.

Related Content:

Pseudomonas Overgrowth in the Gut: Symptoms, Challenges, and Treatment Options

The Top 7 Symptoms of a Candida Overgrowth in the Gut

Gut Motility Isn’t the Problem. Here’s What Is.

Gut-Sinus Connection: The Surprising Link Between Gut Health and Chronic Sinus Problems

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