How Many Antibiotics Does it Take to Mess Up Your Microbiome?
Dr Stephen Wangen
|
February 19, 2025
🦠 How Antibiotics Affect Your Gut Microbiome
People with digestive problems often worry about antibiotics, and they wonder how far of a setback taking antibiotics will be. It’s a really good question, and one that you should be asking yourself every time you need antibiotics. Let’s get into all of the details about how antibiotics affect the microbiome in your gut.
🧬 Experience and Expertise
In my 25-year career I’ve tested the microbiome of thousands of patients. I may even be one of the most clinically experienced doctors in the country in understanding how the microbiome in your gut affects your overall health and your digestion, because I don’t just read about it in journals, I get to see exactly how it plays out in my patients every day.
🧫 A healthy and normal gut microbiome is filled with trillions of bacteria.
🔬 These bacteria can be categorized into around 500 or so different species in the typical person, and around 100 or so different genera.
🦠 As a reminder, Lactobacillus is a genus, and Lactobacillus acidophilus is a species of Lactobacillus. There are other species of Lactobacillus as well.
“As you can see, there are a lot of different types of bacteria that make up your microbiome.”
💊 How Antibiotics Impact Your Gut
As you probably know, when you take an antibiotic, you kill some of the normal good bacteria in your gut.
⚡ This is significant, but maybe not nearly as wild of a killing spree as you might have been led to believe.
🧬 Different types of antibiotics are designed to target different types of bacteria.
❌ Even strong broad-spectrum antibiotics do not sterilize your gut. It’s impossible.
Antibiotics do not clear out all of the bacteria in your gut. But they do have a significant impact on your microbiome.
🌱 Depending upon the makeup of the bacteria in your gut, antibiotics can have a more significant impact in some people than in others.
💩 That’s why when you take an antibiotic, some people get symptoms (like diarrhea), and others don’t.
⚠️ Common Misconceptions
❌ Not finishing your antibiotic does not cause antibiotic resistance in bacteria. That’s a myth.
🕒 In reality, the longer you are on an antibiotic, the greater the chance that antibiotic resistance will develop.
⏳ Long-Term Effects
The impact of antibiotics is much longer lasting than you may think. Once you’ve taken an antibiotic, that’s not the end of the story.
🧩 Antibiotics also have a cumulative effect over years and decades.
🌍 All of the bacteria in your gut are competing for territory.
⚔️ Antibiotics alter the playing field, allowing organisms that are not sensitive to survive and gain more territory.
🦠 Bacteria not affected by the antibiotic
🧬 Bacteria with resistance to that antibiotic
🍄 Yeast or Candida that don’t respond to most antibiotics
“Every time you take an antibiotic, these organisms gain an advantage and flourish. That advantage continues to grow over time.”
📈 Cumulative Effects Over Time
People often tell me that they only had antibiotics a few times as a child, maybe once or twice a year for a few years, and then only a few times since. But those all add up.
⚠️ The cumulative effect can be huge.
🍄 For example, your Candida may start to gain territory when you have antibiotics as a child.
⏳ Over the years, it gradually grows stronger, eventually causing problems in adulthood.
🧬 By this point, your microbiome is very different than it was originally.
🍬 Lifestyle factors like sugar intake and alcohol can further compound the effect.
🛡 Supporting Your Microbiome
🥛 You can’t always rely on probiotics to return your gut to baseline immediately.
💊 Probiotics should be taken every time you use antibiotics.
🌿 Your microbiome is like any other ecosystem—once damaged, it takes effort to restore, but it’s absolutely possible.
“Once the normal environment has been damaged, it can take a lot of work to get it back. But it is doable.”
This post is sponsored by the IBS Treatment Center, where helping people rebuild their microbiome is what we do best.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla, ut commodo diam libero vitae erat. Aenean faucibus nibh et justo cursus id rutrum lorem imperdiet. Nunc ut sem vitae risus tristique posuere.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla, ut commodo diam libero vitae erat. Aenean faucibus nibh et justo cursus id rutrum lorem imperdiet. Nunc ut sem vitae risus tristique posuere.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla, ut commodo diam libero vitae erat. Aenean faucibus nibh et justo cursus id rutrum lorem imperdiet. Nunc ut sem vitae risus tristique posuere.